Analysis of over-the-counter dietary supplements

Citation
Ga. Green et al., Analysis of over-the-counter dietary supplements, CLIN J SPOR, 11(4), 2001, pp. 254-259
Citations number
24
Categorie Soggetti
Ortopedics, Rehabilitation & Sport Medicine
Journal title
CLINICAL JOURNAL OF SPORT MEDICINE
ISSN journal
1050642X → ACNP
Volume
11
Issue
4
Year of publication
2001
Pages
254 - 259
Database
ISI
SICI code
1050-642X(200110)11:4<254:AOODS>2.0.ZU;2-M
Abstract
Objective: To determine if steroids containing over-the-counter (OTC) dieta ry supplements conform to the labeling requirements of the 1994 Dietary Sup plement Health and Education Act (DSHEA). Design: 12 brands of OTC supplements containing 8 different steroids were r andomly selected for purchase in stores that cater to athletes. There are t wo androstenediones (4- and 5-androstene-3,17-dione), two androstenediols ( 4- and 5-androstene-3 beta, 17 beta -diol), and 4 more are 19-nor cogeners (19-nor-4-and 5-androstene-3,17-dione and 19-nor-4- and 5-androstene-3 beta , 17 beta -diol). Main Outcome Measures: 12 brands of OTC anabolic-androgenic supplements wer e analyzed by high-pressure liquid chromatography. Results: We found that 11 of 12 brands tested did not meet the labeling req uirements set out in the 1994 Dietary Supplement Health and Education Act. One brand contained 10 mg of testosterone, a controlled steroid, another co ntained 77% more than the label stated, and 11 of 12 contained less than th e amount stated on the label. Conclusions: These mislabeling problems show that the labels of the dietary steroid supplements studied herein cannot be trusted for content and purit y information. In addition, many sport organizations prohibit OTC steroids; thus, athletes who use them are at risk for positive urine test results. I n this article we provide the details of the analyses, a summary of the ste roids by name and structure, and information on the nature of the positive test results. Athletes and their physicians need this information because o f the potential medical consequences and positive urine test results.