Studies performed to date on the prevalence of biliary lithiasis (BL) in ch
ronic renal failure patients on hemodialysis. (HD) have given contradictory
results. The aims of the present study were to evaluate the prevalence of
BL and its main associated risk factors in a population of hemodialysis pat
ients, and to compare the results with those we had obtained previously in
an overt population of the same zone. The study included 171 patients (83 M
, 88 F), mean age 62.5 years and mean duration of dialysis 66.7 months. The
screening protocol also included body mass index (BMI), a number of bioche
mical parameters and an ultrasound scan of the gallbladder and biliary trac
t. The general prevalence of BL was 33.3% (30.1% in men and 36.4% in women)
, and this figure was significantly higher than that found in our previous
study. Prevalence increased with age in both sexes (Mantel-Haenszel Chi-squ
ared = 5.4, p < 0.03), but not with duration of dialysis. The main risk fac
tors, evaluated with multiple logisstic regression, were the presence of di
abetes mellitus and high serum phosphorus levels. Specific symptoms were al
so significantly associated in BL patients. No association was found with p
arity, BMI or serum lipid alterations. In conclusion, the prevalence of BL
in a Sicilian population of HD patients was higher than that found in an ov
ert population of the same area and the associated main risk factors were n
ot coincident. Further studies are needed to establish the role played by t
he phase of end-stage renal disease before HD and to correct the metabolic
disturbances to limit a high percentage of morbidity in a disease already i
n itself sufficiently disabling.