The surgical findings in 147 consecutive hands that underwent primary carpa
l tunnel release between 1983 and 1993 were reviewed for anatomic variation
. A classification is introduced for the two major types of variations foun
d. The variations found within the carpal tunnel, termed intrinsic or Type
I, were space-occupying lesions of muscular, bony, or varied soft tissue or
igin. The variations overlying the transverse carpal ligament, termed extri
nsic or Type II, were nearly all muscular in origin. Seventy-four variation
s were found in 60 hands. Overall, an underlying variation was found in 41%
of the hands. After applying a logistic model, it was found that patient a
ge and hand dominance were important factors in predicting the presence of
an anatomic variation. For patients 40 years of age or younger, the odds of
observing an anatomic variation were 3.2 times higher than the odds of obs
erving a variation in patients older than 40 years. The odds of observing a
n anatomic variation in the dominant hand were 2.3 times higher when compar
ed with the odds of observing a variation in the nondominant hand. In patie
nts 40 years of age or younger, with dominant side involvement, an anatomic
variation was found in 71% of hands. In patients older than 40 years with
nondominant side involvement, an anatomic variation was found in 24% of han
ds. Taking into account not only anatomic variations but also underlying me
dical disease and local injury, at least one was identified in 86% of hands
.