AN ASSOCIATION BETWEEN INCREASED SERUM-SOLUBLE INTERLEUKIN-2 RECEPTORS AND A DISTURBANCE IN MUSCLE FORCE IN SCHIZOPHRENIC-PATIENTS

1. Serum-soluble interleukin-2 receptors (SIL-2Rs) a sign of immune ac tivation, are increased in approximately 30% of schizophrenic subjects . 2. In a recent publication the authors found that SIL-2Rs were parti cularly elevated in schizophrenic subjects with tardive dyskinesia (TD ). 3. This paper investigates the relationship between muscle force in stability and SIL-2Rs in 32 schizophrenic patients, 10 of whom were ne uroleptic-naive. 4. The authors hypothesized that there would be a pos itive correlation between increased levels of SIL-2Rs and muscle force instability. 5. Serum SIL-2Rs and muscle force instability were posit ively correlated (r = 0.54, p <.001) in the schizophrenic patients, an d this correlation held even for the subset of neuroleptic-naive patie nts (r =.73, df 8, p =.016). 6. These findings suggest that there is a n important correlation between immune activation and muscle force ins tability in schizophrenic patients.