Putting the stress on senescence

Authors
Serrano, M Blasco, MA
Citation
M. Serrano et Ma. Blasco, Putting the stress on senescence, CURR OP CEL, 13(6), 2001, pp. 748-753
Citations number
63
Categorie Soggetti
Cell & Developmental Biology
Journal title
CURRENT OPINION IN CELL BIOLOGY
ISSN journal
09550674 → ACNP
Volume
13
Issue
6
Year of publication
2001
Pages
748 - 753
Database
ISI
SICI code
0955-0674(200112)13:6<748:PTSOS>2.0.ZU;2-H
Abstract
Cultivation of primary cells over many generations eventually results in a reproducible loss of proliferative potential that has been termed 'replicat ive senescence' . Recent work has revealed the heterogeneity of senescence. Importantly, the analysis of the various aspects and types of senescence h as turned out to be very informative about numerous in vivo processes, and particularly about carcinogenesis.