Histopathologic evaluation of a new dermal allograft following explantation

Background. Numerous materials have been used to accomplish soft tissue aug mentation, but the ideal implant remains elusive. Dermaplant is a recently introduced soft tissue matrix derived from human cadaveric dermis and inten ded for use in soft tissue reconstruction. This product is U.S. Food and Dr ug Administration (FDA) approved, but there is a paucity of data regarding its clinical performance. Objective. To report histopathologic findings of an explanted Dermaplant sp ecimen. Methods. A healthy 52-year-old man underwent repair of post-blepharoplasty eyelid retraction and a prominent tear trough defect. At the patient's requ est the tear trough implant was removed in the seventh postoperative week. Gross and microscopic evaluations were performed. Results. Fibroblastic infiltration and new collagen production were demonst rated within the implant and at its periphery. Occasional macrophages and g iant cells were also noted around the implant. Conclusion. In this patient the Dermaplant was well tolerated and supported ingrowth of host tissues. The behavior of this material over the long-term cannot be extrapolated from this study.