ANX7 as a bio-marker in prostate and breast cancer progression

Authors
Srivastava, M Bubendorf, L Nolan, L Glasman, M Leighton, X Miller, G Fehrle, W Raffeld, M Eidelman, O Kallioniemi, OP Srivastava, S Pollard, HB
Citation
M. Srivastava et al., ANX7 as a bio-marker in prostate and breast cancer progression, DIS MARKER, 17(2), 2001, pp. 115-120
Citations number
46
Categorie Soggetti
Medical Research Diagnosis & Treatment
Journal title
DISEASE MARKERS
ISSN journal
02780240 → ACNP
Volume
17
Issue
2
Year of publication
2001
Pages
115 - 120
Database
ISI
SICI code
0278-0240(2001)17:2<115:AAABIP>2.0.ZU;2-Y
Abstract
The ANX7 gene codes for a Ca2+-activated GTPase, which has been implicated in both exocytotic secretion in cells and control of growth. In this review , we summarize information regarding increased tumor frequency in the Anx7 knockout mice, ANX7 growth suppression of human cancer cell lines, and ANX7 expression in human tumor tissue micro-arrays. The loss of ANX7 is signifi cant in metastatic and hormone refractory prostate cancer compared to benig n prostatic hyperplasia. In addition, ANX7 expression has prognostic value for predicting, survival of breast cancer patients.