PURPOSE: Retroflexion of the endoscope during rectal examination may increa
se diagnostic yield but is not routinely performed because of concerns abou
t safety and a lack of appreciation of its importance. The purpose of this
study was to examine the yield, safety, and tolerance of endoscopic rectal
retroflexion. METHODS: Prospective cohorts of subjects undergoing unsedated
screening flexible sigmoidoscopy were examined with and without routine re
troflexion. Pain scores were recorded. RESULTS: A total of 526 subjects (me
an age 60 (range, 55-66) years) underwent flexible sigmoidoscopy in the fir
st period when the endoscope was not routinely retroflexed. Of these, 480 (
mean age 60 (range, 55-66) years) were subsequently examined with routine r
etroflexion. Retroflexion was impossible in 17 subjects (3.5 percent) becau
se of discomfort. In the second group, 12 subjects (2.5 percent) had polyps
in the lower rectum seen only on retroflexion. Of these, eight had metapla
stic and four had adenomatous polyps (3 tubular < 5 nim, I tubulovillous 15
mm). There was no difference in mean pain scores between the groups (no re
troflexion = 2.13, retroflexion = 2.18). CONCLUSION: With an adenoma pick-u
p rate of 8 to 12 percent for screening flexible sigmoidoscopy, retroflexio
n increases adenoma detection by approximately 1 percent without adverse ef
fects an should be an integral part of flexible sigmoidoscopy.