Naltrexone is a long acting opioid antagonist that is used in rehabilitatio
n programmes to maintain heroin abstinence. It is a relatively new drug pre
scribed by specialists in substance misuse. Its actions and effects may not
be familiar to many accident and emergency doctors or even to the people w
ho take it. A case report is described where accidental ingestion of naltre
xone results in a medical emergency by precipitating acute withdrawal in a
heroin addict.