Synthesis and pharmacological study of ethyl 1-methyl-5-(substituted 3,4-dihydro-4-oxoquinazolin-3-yl)-1H-pyrazole-4-acetates

Several new ethyl 1-methyl-5-(substituted 3,4-dihydro-4-oxoquinazolin-3-yl) -1H-pyrazole-4-acetates 2, substituted at 2 and, alternatively at, 6, 7 or 8 positions of the quinazolinone nucleus, were synthesised. The compounds w ere screened for their analgesic and antiinflammatory activities, acute tox icity and ulcerogenic effect. Substitution in the benzene moiety of the qui nazolinone ring did not show any advantage for the analgesic activity, wher eas it improved in some cases the antiinflammatory activity. Some compounds showed appreciable antiinflammatory activity and, at the same time, very l ow ulcerogenic index. (C) 2001 Editions scientifiques et medicales Elsevier SAS.