Regulation of colony stimulating factor-1 (CSF-1) in endometrial cells: glucocorticoids and oxidative stress regulate the expression of CSF-1 and itsreceptor c-fms in endometrial cells
K. Gill et al., Regulation of colony stimulating factor-1 (CSF-1) in endometrial cells: glucocorticoids and oxidative stress regulate the expression of CSF-1 and itsreceptor c-fms in endometrial cells, FERT STERIL, 76(5), 2001, pp. 1005-1011
Objective: To evaluate the regulation and expression of CSF-1 and its recep
tor c-fins in endometrial cells.
Design: In vitro study.
Setting: Research and teaching institution.
Patient(s): None.
Intervention(s): In vitro experimental study.
Main Outcome Measure(s): The effect of glucocorticoid and oxidative stress
on the expression of CSF-1 and c-fins in endometrial cells.
Result(s): Cultured nonmalignant EM42 cells not only express CSF-1 and c-fm
s but are also capable of responding to exogenous CSF-1. We have also seen
that glucocorticoids can regulate the expression of CSF-1/c-fins in endomet
rial cells. Furthermore, this study shows that oxidative stress plays a sig
nificant role in the induction of CSF-1 and its receptor c-fins.
Conclusion(s): The results suggest that CSF-1 may promote the growth of non
malignant endometrial cells in both an autocrine and paracrine manner and t
hat endometrial cells under oxidative stress induce CSF-1 and c-fins. (C) 2
001 by American Society for Reproductive Medicine.