Successful pregnancy after high-dose cyclophosphamide, carboplatinum, and taxol with peripheral blood stem cell transplant in a young woman with ovarian carcinoma

Background. Both ovarian carcinoma and high-dose chemotherapy tend to precl ude future pregnancies. Case. We report a case of a young woman with borderline ovarian carcinoma a nd invasive tumor implants who underwent surgical debulking with preservati on of future fertility followed by carboplatinum, paclitaxel (Taxol), and s ubsequent high-dose chemotherapy with subsequent peripheral blood stem cell rescue as part of a phase I clinical trial. After a brief period of amenor rhea, the patient had a successful pregnancy that was complicated by a spon taneous abortion in the first trimester. Several months later she conceived and delivered a healthy baby at term. Conclusions. To our knowledge this is the first reported case of pregnancy, after high-dose chemotherapy with stem cell transplant in a woman with ova rian carcinoma. (C) 2001 Academic Press.