Kallmann's syndrome: pregnancy through intracytoplasmic sperm injection and complicated by gestational diabetes

Kallmann's syndrome is characterized by hypogonadotropic hypogonadisin and anosmia. Assisted reproductive techniques such as intracytoplasmic sperm in jection (ICSI) may be required to treat the infertile couple with oligozoos permia. Rare complications have been described in patients with Kallinann's syndrome, bw gestational diabetes lias wt previously been reported. A case of Kallinann's syndrome with infertility is reported. Ovulation was successfully induced by human menopausal gonadotropin therapy, but pregnanc y could not be achieved by artificial insemination or by conventional in vi tro fertilization, although the husband had only moderate oligozoospermia. A high fertilization rate of the retrieved oocytes and successful pregnancy was achieved by ICSI. The pregnancy was complicated by gestational diabete s that was managed by insulin therapy. Successful ovulation induction by Kallmann's syndrome is not rare, but ICSI may be needed in selected cases. Some recent data have suggested that diab etes nay occur in patients with Kallmann's syndrome, but further investigat ion is needed to establish whether gestational diabetes is associated with Kallinann's syndrome is purely coincidental.