A case of trisomy 28 in cattle revealed by both banding and FISH-mapping techniques

A case of presumed trisomy 22 in cattle, as earlier reported, was investiga ted by using both chromosome banding and FISH-mapping techniques. A one yea r old Hereford female calf showed slow growth, wbrachygnathia superior, hyp er-salivation, strabisbusmus convergence, macroclitoris and supernumerary n ipples. At necropsy, a duplication of the uterine cervix and an extra aorti c cusp were also observed. The R-banding technique revealed that BTA28 (not BTA22, as erroneously earlier reported) was involved in the trisomy. This was confirmed by FISH-mapping with chromosome-specific markets. phenotypic characteristics achieved in cattle carrier and those earlier reported in hu mans carrying partial trisomy 10 were discussed.