OBJECTIVE: To determine modifiable risk factors for nosocomial Clostridium
difficile-associated diarrhea (CDAD).
DESIGN: Case-control study.
SETTING: 300-bed tertiary-care hospital.
PARTICIPANTS: Hospital inpatients present during the 3-month study period.
METHODS: Case-patients identified with nosocomial CDAD over the study perio
d were compared to two sets of control patients: inpatients matched by age,
gender, and date of admission; and inpatients matched by duration of hospi
tal stay. Variables including demographic data, comorbid illnesses, antibio
tic exposure, and use of gastrointestinal medications were assessed for cas
e- and control-patients. Conditional logistic regression was performed to i
dentify risk factors for nosocomial CDAD.
RESULTS: 27 case-patients were identified and were compared to the two sets
of controls (1:1 match for each comparison set). For the first set of cont
rols, use of ciprofloxacin (odds ratio [OR], 5.5; 95% confidence interval [
CI95], 1.2-24.8; P=.03) was the only variable that remained significant in
the multivariable model. For the second set of controls, prior exposure to
cephalosporins (OF 6.7; CI95, 1.3-33.7; P=.02) and to ciprofloxacin (OF, 9.
5; CI95, 1.01-88.4; P=.05) were kept in the final model.
CONCLUSIONS: Along with cephalosporins, prior quinolone use predisposed hos
pitalized patients to nosocomial CDAD. Quinolones should be used judiciousl
y in acute-care hospitals, particularly in those where CDAD is endemic.