Antimicrobial susceptibility of nasopharyngeal isolates of Haemophilus influenzae from healthy children in day-care centres: results of multicentre study in Russia

Resistance or Haemophilus influenzae from clinical isolates can be predicte d on the basis of results of antimicrobial susceptibility of nasopharyngeal isolates. The carriage rate and the antimicrobial susceptibility of H. inf luenzae isolated in healthy children attending day-care centres in Moscow, Smolensk and Yartsevo was studied. The susceptibility of ampicillin, amoxyc illin/clavulanate, cefaclor. erythromycin, roxithromycin, clarithromycin an d trimethoprim - sulphamethoxazole were determined by the E-test The mean c arriage rate of H. influenzae was 44%, Resistance of H. influenzae to ampic illin was 2.3%, to amoxycillin clavulanate 0.7%, to cefaclor 0.7%, to clari thromycin 18.7% and to trimethoprim-sulphamethoxazole 21%. These included s trains that showed intermediate-resistance. The antimicrobial resistance pr ofiles varied in different centres. The clinical use of trimethoprimsulpham ethoxazole should be restricted because of the high resistance of H. influe nzae to antifolate compounds. (C) 2001 Elsevier Science B.V. and nternation al Society of Chemotherapy. All rights reserved.