Multicentre study of the in vitro evaluation of moxifloxacin and other quinolones against community acquired respiratory pathogens

The in vitro activity of moxifloxacin was compared with that of ciprofoxaci n, levofloxacin, ofloxacin and trovafloxacin against 710 strains (180 Strep tococcus pneumoniae, 180 Haemophilus influenzae, 160 Moraxella catarrhalis and 190 Streptococcus pyogenes) isolated from patients with community-acqui red respiratory tract infections. MIC values for moxifloxacin, trovafloxaci n were 0.25/0.25 0.03/0.03. 0.06, 0.03 and 0.125/0.0125 mg/l for S. pneumon iae, H. influenzae, M. catharralis and S. pyogenes. Based upon the MIC90 va lues and the MIC distributions. moxifloxacin and trovafloxacin were the mos t active of the quinolones tested. They showed enhanced activity against Gr am-positive organisms including penicillin non susceptible S. pneumoniae st rains. Moxifloxacin was also highly active against ciprofloxacin-resistant S. pneumoniae strains. (C) 2001 Published by Elsevier Science B.V. on behal f of the International Society of Chemotherapy.