Trifluoperazine: a broad spectrum bactericide especially active on staphylococci and vibrios

Trifluoperazine showed some significant antimicrobial activity when tested against 293 strains from two Gram-positive and eight Gram-negative genera. Minimum inhibitory concentrations of the drug were measured using an agar d ilution technique. Forty six of 55 strains of Staphylococcus aureus were in hibited by 10-50 mug/ml of trifluoperazine. This drug also inhibited strain s of Shigella spp. Vibrio cholerae and V. parahaemolyticus at a concentrati on of 10-100 mug/ml. Other bacteria including Pseudomonas spp. were moderat ely sensitive to trifluoperazine. In the in vivo studies this compound offe red significant protection to Swiss albino mice at a concentration of 30 mu g/mouse (P < 0.001) when challenged with 50 median lethal dose of Salmonell a typhimurium NCTC 74. (C) 2001 Elsevier Science B.V. and International Soc iety of Chemotherapy. All rights reserved.