R. Mazumder et al., Trifluoperazine: a broad spectrum bactericide especially active on staphylococci and vibrios, INT J ANT A, 18(4), 2001, pp. 403-406
Trifluoperazine showed some significant antimicrobial activity when tested
against 293 strains from two Gram-positive and eight Gram-negative genera.
Minimum inhibitory concentrations of the drug were measured using an agar d
ilution technique. Forty six of 55 strains of Staphylococcus aureus were in
hibited by 10-50 mug/ml of trifluoperazine. This drug also inhibited strain
s of Shigella spp. Vibrio cholerae and V. parahaemolyticus at a concentrati
on of 10-100 mug/ml. Other bacteria including Pseudomonas spp. were moderat
ely sensitive to trifluoperazine. In the in vivo studies this compound offe
red significant protection to Swiss albino mice at a concentration of 30 mu
g/mouse (P < 0.001) when challenged with 50 median lethal dose of Salmonell
a typhimurium NCTC 74. (C) 2001 Elsevier Science B.V. and International Soc
iety of Chemotherapy. All rights reserved.