O. Kirimli et al., The effects of captopril on serum digoxin levels in patients with severe congestive heart failure, INT J CL PH, 39(7), 2001, pp. 311-314
Citations number
16
Categorie Soggetti
Pharmacology & Toxicology
Journal title
INTERNATIONAL JOURNAL OF CLINICAL PHARMACOLOGY AND THERAPEUTICS
The effects of captopril on serum digoxin concentrations were studied in 8
patients with severe (NYHA Class IV) congestive heart failure. Serum digoxi
n concentrations were determined before and after the administration of cap
topril for 1 week in patients on chronic digoxin therapy, Each patient who
was taking 0.25 mg of digoxin PO q.d., was administered 12.5 mg of captopri
l PO t.i.d. for 7 days. The peak serum concentration of digoxin (C-max) bef
ore and after (on Days 0 and 7) captopril administration was 1.7 +/- 0.2 ng
/ml and 2.7 +/- 0.2 ng/ml, the time to peak (t(max)) was 2.4 +/- 0.5 h and
1.3 +/- 0.2 h, and the area under the 24-hour digoxin concentration-time cu
rve (AUC(0-24h)) was 30.0 +/- 1.5 ngxh/ml and 41.7 +/- 3.4 ngxh/ml, respect
ively. While captopril caused a significant increase in peak serum concentr
ation and the area under the digoxin concentration-time curve, it decreased
the time to digoxin peak (p = 0.01, p = 0.04, p = 0.01, respectively). No
patient developed evidence of digoxin toxicity. Concomitant administration
of captopril with digoxin increases serum digoxin concentration in patients
with severe congestive heart failure.