Asian breast cancer survival in the US: a comparison between Asian immigrants, US-born Asian Americans and Caucasians

Background This study examines whether acculturation of Asian American wome n, assessed by place of birth, is associated with survival after diagnosis of breast cancer. We hypothesized that environmental factors associated wit h acculturation, such as a high-fat diet, would result in a pattern of bett er survival for first-generation Asians compared with subsequent-generation Asian Americans. Methods Analyses compare survival among women of four ethnic groups (Chines e [n = 1842], Japanese [n = 3319], Filipino [n = 1598] and a random sample of Caucasians [n = 10 000]) who were diagnosed with primary invasive breast carcinoma in three Surveillance, Epidemiology, and End Results Program (SE ER) regions (San Francisco/Oakland, Hawaii, Seattle/Puget Sound) between 19 73 and 1994. Analyses by birthplace compare first-generation Asian immigran ts with subsequent-generation Asian Americans of the same ethnicity. Analys es were based on the Cox proportional hazards model and adjusted for age at diagnosis, stage of disease, year of diagnosis, type of treatment, marital status, and SEER region. Results Japanese women had significantly better survival than all other rac es, but there were no significant differences in survival between Chinese, Filipino, and Caucasian women. There were no significant differences in sur vival by place of birth within each Asian ethnic group, after adjustment fo r demographic characteristics, stage of disease, and treatment. Conclusions The findings do not support the hypothesis that acculturation o f Asian American women is associated with decreased breast cancer survival.