S. Houterman et al., Trends in total and high density lipoprotein cholesterol and their determinants in The Netherlands between 1993 and 1997, INT J EPID, 30(5), 2001, pp. 1063-1070
Citations number
39
Categorie Soggetti
Envirnomentale Medicine & Public Health","Medical Research General Topics
Background The aim of this study is to describe trends in plasma total and
high density lipoprotein (HDL) cholesterol in The Netherlands between 1993
and 1997 and to examine whether these trends in cholesterol could be explai
ned by changes in body mass index, smoking, alcohol intake, use of choleste
rol lowering medication, intake of saturated fat, trans fatty acids and die
tary cholesterol.
Methods Each year a random sample of men and women aged 20-59 years living
in three towns in The Netherlands was invited to participate in the study.
In total more than 21 000 people were examined.
Results Between 1993 and 1997 plasma total cholesterol decreased significan
tly by 0.19 mmol/l in men and by 0.27 mmol/l in women. During this period H
DL cholesterol remained stable in both men and women. Small decreases were
observed in the intake of saturated fat, trans fatty acids and dietary chol
esterol in both, men and women. The use of cholesterol lowering medication
and for women oral contraceptives and prescribed oestrogens increased signi
ficantly. After adjustment for these determinants in multivariate analyses
the trend in total cholesterol remained highly significant.
Conclusions Between 1993 and 1997 the mean total cholesterol level decrease
d significantly while the mean HDL cholesterol remained stable in both men
and women in The Netherlands. The observed trend in total cholesterol could
only for a small part be explained by changes in the determinants studied.