Second transplantation with CD34(+) blood cells from an HLA-mismatched related donor after engraftment failure of transplanted cord blood cells

Authors
Ohta, H Kim, JY Sawada, A Tokimasa, S Fujisaki, H Matsuda, Y Osugi, Y Hara, J
Citation
H. Ohta et al., Second transplantation with CD34(+) blood cells from an HLA-mismatched related donor after engraftment failure of transplanted cord blood cells, INT J HEMAT, 74(3), 2001, pp. 338-341
Citations number
20
Categorie Soggetti
Hematology
Journal title
INTERNATIONAL JOURNAL OF HEMATOLOGY
ISSN journal
09255710 → ACNP
Volume
74
Issue
3
Year of publication
2001
Pages
338 - 341
Database
ISI
SICI code
0925-5710(200110)74:3<338:STWCBC>2.0.ZU;2-8
Abstract
Unrelated cord blood transplantation (CBT) has been worldwide for bone marr ow reconstitution. CBT is associated with a high frequency of engraftment f ailure and rejection due to a small dose of graft cells. In cases of engraf tment failure or rejection following unrelated CBT retransplantation from t he original donors is impossible. We report a successful transplantation wi th CD34(+) blood cells selected from a 2-loci HLA-mismatched mother to a ch ild with acute monocytic leukemia after engraftment failure of the primary CBT. Selected CD34(+) blood cell transplantation is a useful approach for r etransplantation in the setting of engraftment failure. (C) 2001 The Japane se Society of Hematology.