Five-year results of deep sclerectomy with collagen implant

Purpose. To study prospectively the success rate and complications of deep sclerectomy with collagen implant (DSCI), a nonpenetrating filtration proce dure. Setting. Glaucoma Unit, Department of Ophthalmology, Hopital Ophtalmique Ju les Gonin, University of Lausanne, Lausanne, Switzerland. Methods: This nonrandomized prospective trial comprised 105 eyes of 105 pat ients with medically uncontrolled primary or secondary open-angle glaucoma. Visual acuity, intraocular pressure (IOP), and slitlamp examinations were performed before and after surgery at 1 and 7 days and 1, 3, 6, 9, 12, 18, 24, 30, 36, 48, 54, 60, and 66 months. Visual field examinations were repea ted every 6 months. A qualified success was defined as IOP below 21 mm Hg w ith or without medication. A complete success was defined as IOP lower than 21 mm Hg without medication. Results: The mean follow-up was 43.2 months +/- 14.3 (SID). The mean IOP wa s 26.8 +/- 7 mm Hg preoperatively, 5.1 +/- 3 mm Hg 1 day postoperatively, a nd 11.8 +/- 3 mm Hg 60 months postoperatively. At 60 months, the qualified success rate was 94.8% and the complete success rate, 61.9%. The IOP was lo wer than 21 mm Hg with medication in 32.1% of patients at 60 months; 48 pat ients (45.7%) had an IOP of 15 mm Hg or lower without medication. No patien t developed a shallow or flat anterior chamber, endophthalmitis, or surgery -induced cataract. However, 23 (21.9%) had progression of a preexisting sen ile cataract. Injections of 5-fluorouracil were given to 25 patients (23.8% ) who had DSCI to salvage encysted blebs. The mean number of medications pe r patient was reduced from 2.30 +/- 0.76 to 0.49 +/- 0.72. Conclusion: Deep sclerectomy with collagen implant provided reasonable IOP over a long-term follow-up with few immediate postoperative complications. (C) 2001 ASCRS and ESCRS.