We describe a second cluster of cases of iatrogenic strabismus that occurre
d in clinical practices following cataract surgeries that occurred in 2000
when hyaluronidase was once again unavailable for use in periocular anesthe
tic regimens. Twelve cases of transient or permanent strabismus were referr
ed by 4 anterior segment surgeons who had no previous cases of postcataract
strabismus when performing periocular injections with hyaluronidase. The c
harts of the patients were reviewed retrospectively. Recurrence of an incre
ase in postoperative strabismus when hyaluronidase became unavailable for a
second time supports the concept that this enzyme may be more important th
an previously suspected in preventing damage to the extraocular muscles aft
er periocular anesthetic injections. (C) 2001 ASCRS and ESCRS.