MAG3 RENOGRAM DECONVOLUTION IN KIDNEY-TRANSPLANTATION - UTILITY OF THE MEASUREMENT OF INITIAL TRACER UPTAKE

The study of renal retention function by deconvolution analysis of ren ographic curves is useful to calculate quantitative parameters in rena l studies, The aim of the work is to evaluate the usefulness of Tc-99m -MAG3 renogram deconvolution in renal function monitoring of kidney gr aft recipients, Methods: Forty-three kidney grafts and 112 renograms w ere studied: 41 were diagnosed as functioning graft, 35 as acute tubul ar necrosis, 24 as acute rejection, 8 as obstruction and 4 as cyclospo rin toxicity. The parameters calculated were mean transit time (MT-T), time at 20% of renal retention function (T20) and initial uptake (IU) . Results: MTT and T20 were significantly longer in obstructives than in functioning grafts (p < 0.001), Initial uptake was significantly lo wer in acute tubular necrosis (ATN) and acute rejection (p < 0.001) an d in obstructives (p < 0.05) than in functioning grafts, The joint eva luation of MTT and IU allowed to diagnose cases with graft function se verely impaired, Conclusion: Initial uptake is useful in evaluating po st-transplantation complications and in combination with MTT and T20 r eflects renal dysfunction severity.