A pathological study of tumour regression in oesophageal adenocarcinoma treated with preoperative chemoradiotherapy

Aims-To measure residual tumour in oesophageal adenocarcinoma. treated with preoperative chemoradiotherapy, to correlate specific pathological variabl es with survival, and to describe morphological changes in tumour and non-n eoplastic tissue resulting from preoperative treatment. Methods-Resection specimens from 47 cases of oesophageal adenocarcinoma tre ated with preoperative 5-fluorouracil/cisplatin and radiotherapy were revie wed. Residual tumour was assessed in terms of tumour regression grade (TRG) , pTNM stage, lymphovascular space invasion, and resection margin involveme nt. Survival analysis was performed using the Kaplan-Meier method and log r ank test. Cox's proportional hazard model was used for multivariate analysi s. Results-A complete pathological response (TRG1) was present in eight cases. The absence of residual tumour was confirmed by negative immunohistochemic al staining for MNF116. Tumour corresponding to TRG2 was present in five ca ses, to TRG3 in nine, to TRG4 in 22, and to TRG5 in three. By multivariate analysis, pN0 status (n = 35) had a positive effect on survival (p = 0.04) and TRG had no significant effect on survival (p = 0.06). Patients with pN0 tumours had a median survival of 48 months versus eight months for those w ith pN1 tumours (log rank test, p < 0.0001). We found that giant fibroblast s were discernible from single large residual tumour cells on haematoxylin and eosin alone. Conclusion-Response to preoperative chemoradiotherapy in oesophageal adenoc arcinoma is variable. Although there are as yet no reliable predictors of r esponse to treatment, patients who are identified at diagnosis as having ne gative loco-regional lymph nodes should benefit considerably from this trea tment approach.