OZONOLYSIS OF AZOLES AND ITS APPLICATION TO ORGANIC-SYNTHESIS

Our recent studies concerning the ozonolysis of various azoles are rev iewed in this paper. In spite of their remarkable stabilities under ac idic, basic, oxidative and/or reductive conditions due to their aromat icity, azoles are especially labile toward ozone. The reaction product s and the mechanisms of the ozonolysis of pyrroles, oxazoles, and imid azoles are summarized. Moreover, the ozonolysis of azoles is described in view of its use in the protection-deprotection of functional group s. In particular, the ozonolysis of pyrroles and oxazoles during pepti de synthesis is illustrated.