A model of acute subdural hematoma in the mouse

The availability of genetically modified mice has allowed the study of gene tic influences on acute brain injury. An animal model of acute subdural hem atoma (ASDH) has been previously described in the rat but not the mouse. We describe a method for producing ASDH in the mouse. Subdural injections of 50 and 30 muL of nonheparinized autologous blood were associated with exces sive mortality. Injections of 10 and 20 muL were associated with mean perce ntage volumes of damage of 1.804% and 4.019%, respectively. Sham subdural i njections of saline were associated with minimal hemisphere damage (0.152%) . This mouse model provides a means of investigating the effects of genotyp e on the brain's response to ASDR.