The isolation and synthesis of novel nematocidal dithiocyanates from an Australian marine sponge, Oceanapia sp.

Bioassay-directed fractionation of the EtOH extract of an Oceanapia sp. col lected off the northern Rottnest Shelf, Australia, has yielded three novel dithiocyanates, thiocyanatins A (1), B (2a), and C (2b). The structures wer e determined by detailed spectroscopic analysis and confirmed by total synt hesis. In addition to featuring an unprecedented dithiocyanate functionalit y, thiocyanatins possess an unusual 1,16-difunctionalized n-hexadecane carb on skeleton and are revealed as a hitherto unknown class of nematocidal age nts