The acid-base equilibrium constants of a new family of antihypertensive dru
gs, the angiotensin II receptor antagonists (ARA II), Losartan, Irbesartan,
Valsartan, Candesartan cilexetil, its metabolite Candesartan M1 and Telmis
artan were determined by spectrofluorimetry. Relative fluorescent intensity
(I-F,I-rel)-pH data were treated by graphical (derivatives and curve-fitti
ng) and numerical methods (LETAGROP SPEFO). The resultant pk,, values at an
ionic strength of 0.5 M were (3.15 +/- 0.07) for Losartan, (4.70 +/- 0.06)
for Irbesartan, (4.90 +/- 0.09) for Valsartan, (6.0 +/- 0.1) for Candesart
an cilexetil, (3.9 +/- 0.1) for Candesartan M1, and (4.45 +/- 0.09) for Tel
misartan. (C) 2001 Elsevier Science B.V. All rights reserved.