UV-induced DNA damage, repair, mutations and oncogenic pathways in skin cancer

Citation
Fr. De Gruijl et al., UV-induced DNA damage, repair, mutations and oncogenic pathways in skin cancer, J PHOTOCH B, 63(1-3), 2001, pp. 19-27
Citations number
82
Categorie Soggetti
Biochemistry & Biophysics
Journal title
JOURNAL OF PHOTOCHEMISTRY AND PHOTOBIOLOGY B-BIOLOGY
ISSN journal
10111344 → ACNP
Volume
63
Issue
1-3
Year of publication
2001
Pages
19 - 27
Database
ISI
SICI code
1011-1344(200110)63:1-3<19:UDDRMA>2.0.ZU;2-Q
Abstract
Repair of U-V induced DNA damage is of key importance to UV-induced skin ca rcinogenesis. Specific signal transduction pathways that regulate cell cycl ing, differentiation and apoptosis are found to be corrupted in skin cancer s, e.g., the epidermal growth-stimulating Hedgehog pathway in basal cell ca rcinomas (BCCs). Mutations in genes coding for proteins in these pathways l ead to persistent disturbances that are passed along to daughter cells, e.g ., mutations in the gene for the Patched (PTCH) protein in the Hedgehog pat hway. Thus far only the point mutations in the P53 gene from squamous cell carcinomas and BCCs, and in PTCH gene from BCC of xeroderma pigmentosum (XP ) patients appear to be unambiguously attributable to solar UV radiation. S olar UVB radiation is most effective in causing these point mutations. Othe r forms of UV-induced genetic changes (e.g., deletions) may, however, contr ibute to skin carcinogenesis with different wavelength dependencies. (C) 20 01 Elsevier Science B.V. All rights reserved.