The effects of sprint (300 m) running on plasma lactate, uric acid, creatine kinase and lactate dehydrogenase in competitive hurdlers and untrained men

Background. High intensity exercise may induce muscle damage especially in individuals unaccustomed to regular physical efforts. Our aim was to compar e the impact of 300 to sprint running on muscle enzymes release into blood in competitive hurdlers and untrained but physically fit adults. Methods. Experimental design: comparative study. Setting: general community. Participants: nine competitive hurdlers (CH; 21.3 yrs +/- 3.1) and six matc hed moderately active untrained men (UT). Interventions: subjects performed a single 300 rn sprint running test. Measures: plasma creatine kinase (CK) and lactate dehydrogenase (LD) activi ties, and concentrations of lactate (LA) and uric acid (UA) measured before the warmup and 5 min, 2 and 20 hrs postrun. Results. Mean runner performance achieved by CH was significantly better (3 5.53-s +/-0.64) and LA concentrations significantly higher (14.95 mM +/-0.5 9) than those recorded in UT (41.52-s +/-2.22; 10.13 mM +/-0.59). Pre- and postrun CK activities until the 2nd hour of recovery were found to be signi ficantly higher (p <0.05) in CH than in UT, whereas LD activities were simi lar in both groups pretest, but significantly higher in UT immediately post run. In CH, the highest CK activity (32% increase) was recorded immediately post-test, whereas in UT the peak CK (135 % increase) was attained in the 20th hour of recovery. In both groups UA reached the peak level in the 2nd hour of recovery. Conclusions. More pronounced and delayed postrun increase in CK, as recorde d in UT, may provide evidence of a larger exercise-induced muscle injury in the untrained adults. Higher postexercise UA levels as recorded in CH migh t account for a more marked involvement of adenylate kinase reaction in ATP resynthesis.