Asymmetric catalysis on sequentially-linked columns

We report a catalytic asymmetric reaction process that involves the use of solid-phase reagents and catalysts that constitute the packing of a series of "reaction columns". This process was applied to the catalytic asymmetric synthesis of beta -lactams, to yield pure products with excellent enantio- and diastereoselectivity. We have identified several advantages to conduct ing chemical reactions on sequential columns, including ease of catalyst an d reagent recovery and simplified purification steps that preclude the need for chromatography.