Reductive cyclization with baker's yeast of 4-alkyl-2-nitro-acetanilides to 6-alkylbenzimidazoles and 1-hydroxy-2-methyl-6-alkylbenzimidazoles

Authors
Navarro-Ocana, A Olguin, LF Luna, H Jimenez-Estrada, M Barzana, E
Citation
A. Navarro-ocana et al., Reductive cyclization with baker's yeast of 4-alkyl-2-nitro-acetanilides to 6-alkylbenzimidazoles and 1-hydroxy-2-methyl-6-alkylbenzimidazoles, J CHEM S P1, (21), 2001, pp. 2754-2756
Citations number
34
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
ISSN journal
14727781 → ACNP
Issue
21
Year of publication
2001
Pages
2754 - 2756
Database
ISI
SICI code
1472-7781(20011107):21<2754:RCWBYO>2.0.ZU;2-G
Abstract
Reduction of 4-substituted 2-nitroacetanilides by baker's yeast in acid med ia effected cyclization, resulting in the formation of 6-substituted 2-meth ylbenzimidazoles and 6-substituted 1-hydroxy-2-methylbenzimidazole via the chemo- and regioselective reduction of the 2-nitro aromatic group to amine or hydroxylamine.