Transition metal complexes as linkers for solid phase synthesis: chromium carbonyl complexes as linkers for arenes

Authors
Comely, AC Gibson, SE Hales, NJ Peplow, MA
Citation
Ac. Comely et al., Transition metal complexes as linkers for solid phase synthesis: chromium carbonyl complexes as linkers for arenes, J CHEM S P1, (20), 2001, pp. 2526-2531
Citations number
22
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
JOURNAL OF THE CHEMICAL SOCIETY-PERKIN TRANSACTIONS 1
ISSN journal
14727781 → ACNP
Issue
20
Year of publication
2001
Pages
2526 - 2531
Database
ISI
SICI code
1472-7781(20011021):20<2526:TMCALF>2.0.ZU;2-4
Abstract
Substrates containing aromatic rings have been attached to 'polymer support ed triphenylphosphine' using a chromium carbonyl linker, chemically manipul ated, and released from the polymer to demonstrate the potential use of pi -bound ligands in linker chemistry. Immobilisation of the phenylalanine der ivative Fmoc-Phe-OtBu via its aromatic ring has been achieved and the resul ting resin successfully subjected to standard amino acid deprotection and c oupling procedures.