K. Nishihara et al., Comparison of the upper gastrointestinal effects of etodolac and aspirin in healthy dogs, J VET MED S, 63(10), 2001, pp. 1131-1133
Fifteen healthy castrated male dogs were separated into three treatment gro
ups that were administered etodolac, aspirin and a placebo orally, respecti
vely. All treatments were continued for 28 days. The animals were examined
endoscopically on days 0, 3, 7, 10, 14, 17, 21. 24 and 28. There were no ga
strointestinal mucosal lesions in either the etodolac or the placebo group,
whereas some gastric lesions developed in the aspirin group after day 17.
We considered that etodolac could be used for long-term treatments in dogs
with fewer side-effects on the gastric mucosa than aspirin.