Citation
M. Nakanishi et al., Humoral hypercalcemia of malignancy in female F344 rats implanted with a transplantable rat pulmonary carcinoma line (IP), J VET MED S, 63(10), 2001, pp. 1135-1138
Citations number
12
Categorie Soggetti
Veterinary Medicine/Animal Health
Journal title
JOURNAL OF VETERINARY MEDICAL SCIENCE
ISSN journal
09167250
→ ACNP
Volume
63
Issue
10
Year of publication
2001
Pages
1135 - 1138
Database
ISI
SICI code
0916-7250(200110)63:10<1135:HHOMIF>2.0.ZU;2-8
Abstract
A transplantable rat pulmonary carcinoma line (IP) in F344 rats is a useful
animal model for humoral hypercalcemia of malignancy (HHM). The present st
udy analyzed the degree of HHM by implanting IP into F344 female rats aged
6, 20 or 45 weeks. IP-bearing females developed elevated plasma parathyroid
hormone-related protein levels, hypercalcemia and increased osteoclastic a
ctivity as well as calcification in various organs. The severity of such HH
M differed depending on age; particularly, calcification showed age-depende
nt reduction. HHM development in IP-bearing females may be influenced by ag
e-related factors.