STRUCTURE-ACTIVITY-RELATIONSHIPS OF CARBOCYCLIC INFLUENZA NEURAMINIDASE INHIBITORS

Authors
WILLIAMS MA LEW W MENDEL DB TAI CY ESCARPE PA LAVER WG STEVENS RC KIM CU
Citation
Ma. Williams et al., STRUCTURE-ACTIVITY-RELATIONSHIPS OF CARBOCYCLIC INFLUENZA NEURAMINIDASE INHIBITORS, Bioorganic & medicinal chemistry letters, 7(14), 1997, pp. 1837-1842
Citations number
18
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
14
Year of publication
1997
Pages
1837 - 1842
Database
ISI
SICI code
0960-894X(1997)7:14<1837:SOCIN>2.0.ZU;2-S
Abstract
The structure-activity relationships (SAR) for a new class of potent i nhibitors (1) of influenza neuraminidase are described. Systematic mod ifications of substituents at the C-3, C-4, and C-5 positions of the c arbocyclic ring were performed to establish fundamental SAR to assist in the design of potent inhibitors with activity against both of influ enza A and B viruses. (C) 1997 Elsevier Science Ltd.