AMIDE BACKBONE MODIFICATIONS FOR ANTISENSE OLIGONUCLEOTIDES CARRYING POTENTIAL INTERCALATING SUBSTITUENTS - INFLUENCE ON THE THERMODYNAMIC STABILITY OF THE CORRESPONDING DUPLEXES WITH RNA-COMPLEMENT AND DNA-COMPLEMENT

Authors
DEMESMAEKER A WENDEBORN S JOUANNO C FRITSCH V WOLF RM
Citation
A. Demesmaeker et al., AMIDE BACKBONE MODIFICATIONS FOR ANTISENSE OLIGONUCLEOTIDES CARRYING POTENTIAL INTERCALATING SUBSTITUENTS - INFLUENCE ON THE THERMODYNAMIC STABILITY OF THE CORRESPONDING DUPLEXES WITH RNA-COMPLEMENT AND DNA-COMPLEMENT, Bioorganic & medicinal chemistry letters, 7(14), 1997, pp. 1869-1874
Citations number
16
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
14
Year of publication
1997
Pages
1869 - 1874
Database
ISI
SICI code
0960-894X(1997)7:14<1869:ABMFAO>2.0.ZU;2-B
Abstract
The synthesis of the amide dimers 3-5 carrying a potential intercalati ng substituent on the nitrogen atom of the backbone is presented, toge ther with the incorporation of these modifications into oligonucleotid es, the resulting melting temperatures (T-m's) of the corresponding du plexes with RNA- and DNA- complements and a summary of molecular model ing studies. (C) 1997 Elsevier Science Ltd.