SYNTHESIS AND ANTI-HIV ACTIVITY OF SOME NEW AMINOADAMANTANE HETEROCYCLES

Authors
FYTAS G STAMATIOU G FOSCOLOS GB KOLOCOURIS A KOLOCOURIS N WITVROUW M PANNECOUQUE C DECLERQ E
Citation
G. Fytas et al., SYNTHESIS AND ANTI-HIV ACTIVITY OF SOME NEW AMINOADAMANTANE HETEROCYCLES, Bioorganic & medicinal chemistry letters, 7(14), 1997, pp. 1887-1890
Citations number
7
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
14
Year of publication
1997
Pages
1887 - 1890
Database
ISI
SICI code
0960-894X(1997)7:14<1887:SAAAOS>2.0.ZU;2-U
Abstract
A new class of aminoadamantane heterocycles has been synthesized and e xamined for anti-HIV activity. Three compounds proved to be active aga inst the replication of HIV-1 in MT-4 cells with an EC50 ranging from 3.6 to 75.2 mu M. No activity was noted with any of the compounds agai nst HIV-2. (C) 1997 Elsevier Science Ltd.