SYNTHESIS OF NOVEL TAXOL ANALOGS AND EVALUATION OF THEIR BIOLOGICAL-ACTIVITIES

Authors
WENDER PA LEE DS LAL TK HORWITZ SB RAO S
Citation
Pa. Wender et al., SYNTHESIS OF NOVEL TAXOL ANALOGS AND EVALUATION OF THEIR BIOLOGICAL-ACTIVITIES, Bioorganic & medicinal chemistry letters, 7(14), 1997, pp. 1941-1944
Citations number
38
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
14
Year of publication
1997
Pages
1941 - 1944
Database
ISI
SICI code
0960-894X(1997)7:14<1941:SONTAA>2.0.ZU;2-3
Abstract
Two new taxol analogs 6 and 10 have been prepared from baccatin III (1 ) and taxol (7a), respectively. Like taxol, both compounds were found to promote microtubule formation and stabilization, although they were less active than taxol. Both 6 and 10 exhibited cytotoxicity against J774.2 cells; 6 was similar to 60-fold less active and 10 was similar to 15-fold less active. (C) 1997 Elsevier Science Ltd.