SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIP OF C-3 BENZOYLOXYMETHYLCEPHALOSPORINS EXHIBITING ANTI-MRSA ACTIVITIES

Authors
KIM OK UEDA Y MANSURI MM RUSSELL JW BIDWELL VW
Citation
Ok. Kim et al., SYNTHESIS AND STRUCTURE-ACTIVITY RELATIONSHIP OF C-3 BENZOYLOXYMETHYLCEPHALOSPORINS EXHIBITING ANTI-MRSA ACTIVITIES, Bioorganic & medicinal chemistry letters, 7(14), 1997, pp. 1945-1950
Citations number
11
Categorie Soggetti
Chemistry Inorganic & Nuclear","Chemistry Medicinal
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
14
Year of publication
1997
Pages
1945 - 1950
Database
ISI
SICI code
0960-894X(1997)7:14<1945:SASROC>2.0.ZU;2-M
Abstract
A series of cephalosporins bearing C-3 benzoyloxymethyl groups were pr epared and evaluated for their anti-MRSA activity and plasma stability . They exhibit excellent in vitro activity (MIC = 0.06 similar to 2 mu g/mL) against MRSA and excellent stability in human plasma. (C) 1997 Elsevier Science Ltd.