Extramedullary T lymphoid blast crisis representing an additional translocation, t(6;8)(q25;q22) in a patient with Philadelphia-positive chronic myelogenous leukemia after allogeneic bone marrow transplantation

Authors
Okazuka, K Toba, K Kawai, K Nikkuni, K Tsuchiyama, J Momoi, A Kanazawa, N Nagai, K Suzuki, N Aizawa, Y
Citation
K. Okazuka et al., Extramedullary T lymphoid blast crisis representing an additional translocation, t(6;8)(q25;q22) in a patient with Philadelphia-positive chronic myelogenous leukemia after allogeneic bone marrow transplantation, LEUK RES, 25(12), 2001, pp. 1089-1094
Citations number
29
Categorie Soggetti
Onconogenesis & Cancer Research
Journal title
LEUKEMIA RESEARCH
ISSN journal
01452126 → ACNP
Volume
25
Issue
12
Year of publication
2001
Pages
1089 - 1094
Database
ISI
SICI code
0145-2126(200112)25:12<1089:ETLBCR>2.0.ZU;2-4
Abstract
A patient with extramedullary crisis from chronic myelogenous leukemia afte r allogeneic bone marrow transplantation is reported. A pathological neck l ymph node observed after transplantation revealed pre-T lymphoblastic pheno type, and the fluorescence in situ hybridization (FISH) analysis showed rec ipient type sex chromosomes and bcr/abl fusion gene. The cells represented an additional translocation, t(6;8)(q25;q22). No rearrangements of the T-ce ll receptor (TCR) beta, gamma or delta chain genes were observed. The absen ce of TCR rearrangement indicated the clonogenic. involvement of pluripoten t hematopoietic stem cells by Philadelphia chromosome. Bone marrow specimen s at that time showed donor type sex chromosomes and no bcr/abl-positive ce lls by FISH. (C) 2001 Elsevier Science Ltd. All rights reserved.