Structure-activity relationship studies on the potent multidrug resistance(MDR) modulator 2-(3,4-dimethoxyphenyl)-2-(methylethyl)-5-[(anthr-9-yl)methylamino]pentanenitrile (MM 36)

Authors
Teodori, E Dei, S Garnier-Suillerot, A Quidu, P Scapecchi, S Budriesi, R
Citation
E. Teodori et al., Structure-activity relationship studies on the potent multidrug resistance(MDR) modulator 2-(3,4-dimethoxyphenyl)-2-(methylethyl)-5-[(anthr-9-yl)methylamino]pentanenitrile (MM 36), MED CHEM RE, 10(9), 2001, pp. 563-576
Citations number
34
Categorie Soggetti
Chemistry & Analysis
Journal title
MEDICINAL CHEMISTRY RESEARCH
ISSN journal
10542523 → ACNP
Volume
10
Issue
9
Year of publication
2001
Pages
563 - 576
Database
ISI
SICI code
1054-2523(2001)10:9<563:SRSOTP>2.0.ZU;2-4
Abstract
A few derivatives of the potent MDR inhibitor 2-(3,4-dimethoxyphenyl)-2-(me thylethyl)-5-[(anthr-9-yl)methylamino]pentanenitrile (MM36) have been synth esised and studied with the aim of optimising activity and selectivity. The results show that, even if dramatic improvements in potency and in selecti vity were not reached, a better drug candidate (14) and a new lead for furt her development of the series (8) have been identified.