THE FAD DEPENDENT AMINE OXIDASES IN RELATION TO DEVELOPMENTAL STATE OF ENTEROCYTE

Epithelial cells from bovine and guinea pig small intestines contain m onoamine and polyamine oxidases with MAO-A preponderance at any matura tional stage. For either species, K-m values for 5HT and N(1)acetylspe rmine remain throughout cellular maturation on the same levels, wherea s the V-max values do not. For serotonin, the dividing crypt cells sho wed in cow lower and in guinea pig higher V-max than the mature cells; for N(1)acetylspermine, mature cells, independently of species, showe d lower V-max.