A family outing: small GTPases cyclin' through G1

Authors
Coleman, ML Marshall, CJ
Citation
Ml. Coleman et Cj. Marshall, A family outing: small GTPases cyclin' through G1, NAT CELL BI, 3(11), 2001, pp. E250-E251
Citations number
17
Categorie Soggetti
Cell & Developmental Biology
Journal title
NATURE CELL BIOLOGY
ISSN journal
14657392 → ACNP
Volume
3
Issue
11
Year of publication
2001
Pages
E250 - E251
Database
ISI
SICI code
1465-7392(200111)3:11<E250:AFOSGC>2.0.ZU;2-8
Abstract
Cell proliferation is regulated by temporal changes in gene expression in r esponse to specific chemical and physical cues. These signals are relayed b y a variety of intracellular signalling pathways including those activated by small GTPases, such as Ras, Rho, Rac and Cdc42. In this issue, Assoian a nd colleagues show that Rho confines the expression of cyclin D1 to mid-G1 phase of the cell cycle, by interactions with the ERK and Rac/Cdc42 signall ing pathways.