Jpm. Finberg et al., MODIFICATION OF CEREBRAL CORTICAL NORADRENALINE RELEASE BY CHRONIC INHIBITION OF MAO-A, Journal of neural transmission. Supplementum, (41), 1994, pp. 123-125
Chronic treatment of rats with clorgyline (1 mg/kg i.p. daily for 21 d
ays) caused a highly significant increase in the concentration of nora
drenaline in microdialysate from the frontal cortex of the awake anima
l. Acute (one injection, 2 mg/kg) or subacute (1 mg/kg daily for 3 day
s) treatment did not lead to a significant increase in microdialysate
noradrenaline. Concentrations of deaminated metabolites (DPHG, MHPG, D
OPAC) in the microdialysate decreased with time of treatment, reaching
a minimum after 21 days.