A novel presenilin mutation (M233V) causing very early onset Alzheimer's disease with Lewy bodies

Presenilin 1 mutations are the major cause of autosomal dominant Alzheimer' s disease: here we identify a new missense mutation causing a methionine to valine change at codon 233. This codon is homologous to a pathogenic prese nilin 2 mutation with the same base change (ATG to GTG) and amino acid chan ge (M239V). This mutation causes disease with an exceptionally early onset age (similar to 30 years) in which pathological examination shows extensive Lewy bodies as well as plaques and tangles. (C) 2001 Elsevier Science Irel and Ltd. All rights reserved.