Sl. Gortmaker et al., Effect of combination therapy including protease inhibitors on mortality among children and adolescents infected with HIV-1, N ENG J MED, 345(21), 2001, pp. 1522-1528
Citations number
37
Categorie Soggetti
General & Internal Medicine","Medical Research General Topics
Background: Combination therapy including protease inhibitors has been show
n to be effective in treating adults infected with human immunodeficiency v
irus type 1 (HIV-1), but there are only limited data regarding the treatmen
t of children and adolescents.
Methods: A cohort of 1028 HIV-1-infected children and adolescents, from bir
th through 20 years of age, who were enrolled in research clinics in the Un
ited States before 1996 was followed prospectively through 1999. We used pr
oportional-hazards regression models to estimate the effect on mortality of
combination therapy including protease inhibitors.
Results: Seven percent of the subjects were receiving combination therapy i
ncluding protease inhibitors in 1996; by 1999, 73 percent were receiving su
ch therapy. In univariate analyses, a higher base-line percentage of lympho
cytes that were CD4-positive, a higher weight for age, a higher height for
age, black race, Hispanic ethnic background, younger age, and perinatally a
cquired infection were associated with a longer median time to the initiati
on of this type of therapy (P<0.001). After adjustment for covariates, the
differences among racial and ethnic groups in the time to initiation were n
ot statistically significant. Mortality declined from 5.3 percent in 1996 t
o 2.1 percent in 1997, 0.9 percent in 1998, and 0.7 percent in 1999 (P for
trend <0.001). There were reductions in mortality in all subgroups defined
according to age, sex, percentage of CD4+ lymphocytes, educational level of
the parent or guardian, and race or ethnic background. In adjusted analyse
s, the initiation of combination therapy including protease inhibitors was
independently associated with reduced mortality (hazard ratio for death, 0.
33; 95 percent confidence interval, 0.19 to 0.58; P<0.001).
Conclusions: The use of combination therapy including protease inhibitors h
as markedly reduced mortality among children and adolescents infected with
HIV-1. (N Engl J Med 2001;345:1522-8.) Copyright (C) 2001 Massachusetts Med
ical Society.