A novel route to 2,3-pyrazol-1(5H)-ones via palladium-catalyzed carbonylation of 1,2-diaza-1,3-butadienes

Authors
Boeckman, RK Reed, JE Ge, P
Citation
Rk. Boeckman et al., A novel route to 2,3-pyrazol-1(5H)-ones via palladium-catalyzed carbonylation of 1,2-diaza-1,3-butadienes, ORG LETT, 3(23), 2001, pp. 3651-3653
Citations number
16
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
ORGANIC LETTERS
ISSN journal
15237060 → ACNP
Volume
3
Issue
23
Year of publication
2001
Pages
3651 - 3653
Database
ISI
SICI code
1523-7060(20011115)3:23<3651:ANRT2V>2.0.ZU;2-G
Abstract
[GRAPHICS] A novel Pd(0)-catalyzed carbonylation of both isolable 1,2-diaza-1,3-butadi enes and those generated in situ by extrusion of SO2 and CO2 from heterocyc lic precursors is described. The reaction proceeds at room temperature to 1 10 degreesC under 1-2 atm of CO to afford 2,3-pyrazol-1(5H)-ones in good to excellent yields. The effect of catalyst structure and stability on the ca rbonylation reaction is evaluated.